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KMID : 1004820090100020053
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Journal of Biomedical Research
2009 Volume.10 No. 2 p.53 ~ p.58
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Notch signaling pathway: rational targets for cancer therapy
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Yun Ji-Eun
Han Sang-Bae
Kim Young-Soo
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Abstract
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The Notch signaling pathway regulates cell proliferation, apoptosis and cell fate decision.Recent preclinical and clinical evidence supports a pro-oncogenic function for Notch signaling in severalsolid tumors including breast and prostate cancer. Consequently, there is increasing interest in targeting Notchsignaling therapeutically in cancer patients. Notch inhibitors, particularly gamma-secretase inhibitors, arebeing investigated as candidate cancer therapeutic agents. However, rational targeting of Notch signaling incancer will require a systematic exploration of several areas that remain incompletely understood. Therefore,a clear understanding of the Notch signaling and its cross-talk with other signaling cascade will increase ourability to design rational combination regimens for cancer therapy.
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KEYWORD
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Notch, Signaling, Cancer, Targeted therapy
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